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Get ready to saddle up your taste buds with this hearty, cheesy John Wayne Casserole—an easy-to-make, crowd-pleasing classic that’s straight out of the Wild West! It’s an easy ground beef casserole recipe with a biscuit base and loaded with diced tomatoes, corn, taco seasoning, cream cheese, mozzarella and cheddar.

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John Wayne Casserole is a delicious ground beef and biscuit casserole made with Bisquick.

This simple and flavourful casserole is sure to please the whole family.

This ground beef casserole recipe takes about an hour from start to finish and serves six people.

• 1 lb lean ground beef
• 2 cups water
• 1 oz taco seasoning
• 1 cup diced yellow onion
• 20 oz Rotel diced tomatoes and green chilies, drained
• 12 oz canned corn, drained

Biscuit Layer

• 3 cups Bisquick mix

Topping

• 7.5 oz Philadelphia whipped chive cream cheese
• 1/2 cup mayo
• 1 tbsp garlic powder
• 1/2 tsp salt
• 2 cups shredded mozzarella and cheddar cheese blend

Printable Recipe Card with a Full List of Ingredients and Instructions is Located at the Bottom of the Post.

Be sure to read through the entire post so that you don’t miss out on any important tips and tricks!

I crumbled the ground beef well as it cooked.

Then I added some water and taco seasoning to the pan with the ground beef.

After four minutes, I added some diced onions, two cans of Rotel diced tomatoes and green chilies and some canned corn to the pan with the ground beef.

Then I poured some Bisquick mix into a large mixing bowl.

Then I stirred until a sticky dough formed.

Then I scooped the ground beef mixture on top of the dough and spread it out evenly.

Then I added some garlic powder and salt to the bowl.

I used an electric mixer to cream together the mayo and cream cheese until smooth.

I sprinkled some shredded mozzarella and cheddar cheese on top of the cream cheese mixture.

After 40 minutes I removed the casserole from the oven and left it to sit for a few minutes before slicing and serving.

This cheesy ground beef and biscuit casserole is the perfect comfort food.

The Rotel and taco seasoning give this dish a bit of a kick but it’s not overly spicy.

If you are looking for a tasty casserole recipe using ground beef, then you need to try this John Wayne Casserole!

How should I store this casserole?

Store any leftovers in an airtight container in the refrigerator for up to 3 days. For longer storage freeze for up to 3 months. Reheat thoroughly before serving.

What substitutions could I make?

• Ground Beef: Any ground meat could be used in this recipe including ground turkey, ground chicken and ground pork.
• Mozzarella and Cheddar Cheese: You can experiment with different types of cheese such as Havarti, Swiss or Monterey Jack to suit your taste.
• Cream Cheese and Mayo: Instead of cream cheese and mayo you can use sour cream, plain Greek yogurt or dairy-free yogurt as a substitute. They provide a similar creamy tang to the dish.
• Canned Corn: Feel free to add or swap vegetables based on your preferences. You can include diced bell peppers, peas, carrots, zucchini, or any other vegetables you enjoy.

Remember, substitutions may alter the taste and texture of the casserole slightly, so it’s best to experiment and find combinations that you enjoy.

What should I serve with this casserole?

John Wayne casserole is a hearty dish on its own, but if you’re looking to serve it with some complementary sides, here are a few suggestions:

1. Salad: A fresh green salad with a light dressing can help balance the richness of the casserole. Consider a simple garden salad with mixed greens, cherry tomatoes, cucumbers, and your favorite dressing.
2. Steamed Vegetables: Lightly steamed vegetables like broccoli, cauliflower, or green beans can add a healthy and vibrant element to the meal. Season them with a touch of salt and pepper or a drizzle of lemon juice.
3. Baked Beans: Another popular side dish to serve with casseroles is baked beans. The sweet and savory flavors of baked beans can complement the flavors of the casserole nicely.

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